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| 1st(1st leg) | Criciúma - SC | - | Fluminense RJ | 2:1 (2:1) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Criciúma - SC | 3:0 (1:0) | ||
| 1st(1st leg): 27/07/2021 23:15 | 2nd (2nd leg): 31/07/2021 20:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Vitória - BA | - | Grêmio Porto Alegre | 0:3 (0:1) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Vitória - BA | 1:0 (1:0) | ||
| 1st(1st leg): 28/07/2021 01:30 | 2nd (2nd leg): 03/08/2021 23:00 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Athletico Paranaense | - | Atlético Goianiense | 2:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Goianiense | - | Athletico Paranaense | 2:2 (0:1) | ||
| 1st(1st leg): 28/07/2021 20:30 | 2nd (2nd leg): 04/08/2021 23:15 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Santos FC | - | Juazeirense - BA | 4:0 (0:0) | ||
| 2nd (2nd leg) | Juazeirense - BA | - | Santos FC | 2:0 (2:0) | ||
| 1st(1st leg): 28/07/2021 23:15 | 2nd (2nd leg): 05/08/2021 23:15 | Winner: Santos FC | ||||
| 1st(1st leg) | Atlético Mineiro | - | Bahia - BA | 2:0 (1:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | Atlético Mineiro | 2:1 (2:0) | ||
| 1st(1st leg): 29/07/2021 01:30 | 2nd (2nd leg): 05/08/2021 01:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | São Paulo FC | - | Vasco da Gama - RJ | 2:0 (1:0) | ||
| 2nd (2nd leg) | Vasco da Gama - RJ | - | São Paulo FC | 1:2 (0:1) | ||
| 1st(1st leg): 29/07/2021 01:30 | 2nd (2nd leg): 05/08/2021 01:30 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Fortaleza | - | CR Brasil - AL | 2:1 (0:1) | ||
| 2nd (2nd leg) | CR Brasil - AL | - | Fortaleza | 0:1 (0:1) | ||
| 1st(1st leg): 29/07/2021 20:30 | 2nd (2nd leg): 04/08/2021 20:30 | Winner: Fortaleza | ||||
| 1st(1st leg) | Flamengo RJ | - | ABC - RN | 6:0 (4:0) | ||
| 2nd (2nd leg) | ABC - RN | - | Flamengo RJ | 0:1 (0:0) | ||
| 1st(1st leg): 30/07/2021 00:00 | 2nd (2nd leg): 06/08/2021 01:30 | Winner: Flamengo RJ | ||||
