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| 1st(1st leg) | Marcílio Dias - SC | - | Goianésia - GO | 2:1 (1:1) | ||
| 2nd (2nd leg) | Goianésia - GO | - | Marcílio Dias - SC | 1:1 (1:0) | ||
| 1st(1st leg): 19/12/2020 19:00 | 2nd (2nd leg): 27/12/2020 19:00 | Winner: Marcílio Dias - SC | ||||
| 1st(1st leg) | Goiânia - GO | - | Grêmio Novorizontino - SP | 1:1 (0:1) | ||
| 2nd (2nd leg) | Grêmio Novorizontino - SP | - | Goiânia - GO | 4:0 (1:0) | ||
| 1st(1st leg): 19/12/2020 19:00 | 2nd (2nd leg): 27/12/2020 19:00 | Winner: Grêmio Novorizontino - SP | ||||
| 1st(1st leg) | Globo - RN | - | Fast Clube - AM | 2:1 (0:1) | ||
| 2nd (2nd leg) | Fast Clube - AM | - | Globo - RN | 6:5 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 20/12/2020 18:00 | 2nd (2nd leg): 26/12/2020 20:00 | Winner: Fast Clube - AM | ||||
| 1st(1st leg) | Juventude - MA | - | Floresta - CE | 2:2 (1:0) | ||
| 2nd (2nd leg) | Floresta - CE | - | Juventude - MA | 2:0 (1:0) | ||
| 1st(1st leg): 20/12/2020 18:30 | 2nd (2nd leg): 27/12/2020 19:00 | Winner: Floresta - CE | ||||
| 1st(1st leg) | Mirassol - SP | - | Brasiliense - DF | 4:0 (1:0) | ||
| 2nd (2nd leg) | Brasiliense - DF | - | Mirassol - SP | 2:1 (0:1) | ||
| 1st(1st leg): 20/12/2020 18:30 | 2nd (2nd leg): 27/12/2020 18:00 | Winner: Mirassol - SP | ||||
| 1st(1st leg) | Salgueiro - PE | - | Altos - PI | 1:1 (1:1) | ||
| 2nd (2nd leg) | Altos - PI | - | Salgueiro - PE | 4:2 (1:1, 1:1) pso | ||
| 1st(1st leg): 20/12/2020 19:00 | 2nd (2nd leg): 27/12/2020 18:45 | Winner: Altos - PI | ||||
| 1st(1st leg) | São Luiz - RS | - | Aparecidense - GO | 0:4 (0:1) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | São Luiz - RS | 1:2 (0:0) | ||
| 1st(1st leg): 20/12/2020 20:00 | 2nd (2nd leg): 27/12/2020 19:00 | Winner: Aparecidense - GO | ||||
| 1st(1st leg) | Galvez - AC | - | América - RN | 1:1 (1:0) | ||
| 2nd (2nd leg) | América - RN | - | Galvez - AC | 5:1 (1:0) | ||
| 1st(1st leg): 20/12/2020 21:00 | 2nd (2nd leg): 27/12/2020 19:00 | Winner: América - RN | ||||
