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| 1st(1st leg) | São Paulo FC | - | Athletico Paranaense | 1:1 (0:1) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | São Paulo FC | 1:0 (1:0) | ||
| 1st(1st leg): 27/12/2020 19:00 | 2nd (2nd leg): 03/01/2021 19:00 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Flamengo RJ | - | Fluminense RJ | 3:1 (1:1) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Flamengo RJ | 1:4 (1:0, 3:1, 3:1) pso | ||
| 1st(1st leg): 28/12/2020 18:00 | 2nd (2nd leg): 04/01/2021 18:00 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Palmeiras | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Palmeiras | 1:0 (1:0) | ||
| 1st(1st leg): 29/12/2020 19:00 | 2nd (2nd leg): 03/01/2021 23:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Corinthians SP | - | Grêmio Porto Alegre | 0:0 (0:0) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Corinthians SP | 2:3 (2:0) | ||
| 1st(1st leg): 29/12/2020 19:00 | 2nd (2nd leg): 03/01/2021 19:00 | Winner: Corinthians SP | ||||
