1st(1st leg) Vasco da Gama - Internacional 0:1
2nd (2nd leg) Internacional - Vasco da Gama 3:2
1st(1st leg): 14/05/2021 23:00 2nd (2nd leg): 23/05/2021 00:00 Winner: Internacional
1st(1st leg) Avai - SC - Palmeiras 1:0
2nd (2nd leg) Palmeiras - Avai - SC 1:1
1st(1st leg): 16/05/2021 20:00 2nd (2nd leg): 22/05/2021 17:45 Winner: Avai - SC
1st(1st leg) Coritiba FC - Atlético Mineiro 2:2
2nd (2nd leg) Atlético Mineiro - Coritiba FC 0:2
1st(1st leg): 17/05/2021 00:30 2nd (2nd leg): 22/05/2021 15:00 Winner: Coritiba FC
1st(1st leg) Floresta - CE - Botafogo - RJ 1:2
2nd (2nd leg) Botafogo - RJ - Floresta - CE 3:0
1st(1st leg): 18/05/2021 19:00 2nd (2nd leg): 23/05/2021 14:30 Winner: Botafogo - RJ