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| 1st(1st leg) | Paraná Clube | - | Red Bull Bragantino | 0:1 (0:1) | ||
| 2nd (2nd leg) | Red Bull Bragantino | - | Paraná Clube | 2:1 (0:0) | ||
| 1st(1st leg): 25/08/2022 19:00 | 2nd (2nd leg): 31/08/2022 23:00 | Winner: Red Bull Bragantino | ||||
| 1st(1st leg) | Fortaleza | - | Fluminense - RJ | 2:2 (1:2) | ||
| 2nd (2nd leg) | Fluminense - RJ | - | Fortaleza | 1:0 (0:0) | ||
| 1st(1st leg): 25/08/2022 19:00 | 2nd (2nd leg): 01/09/2022 19:00 | Winner: Fluminense - RJ | ||||
| 1st(1st leg) | Sport Recife - PE | - | Cuiabá - MT | 1:1 (0:0) | ||
| 2nd (2nd leg) | Cuiabá - MT | - | Sport Recife - PE | 2:0 (1:0) | ||
| 1st(1st leg): 25/08/2022 19:00 | 2nd (2nd leg): 31/08/2022 21:00 | Winner: Cuiabá - MT | ||||
| 1st(1st leg) | Vila Nova - GO | - | Grêmio Porto Alegre | 1:0 (1:0) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Vila Nova - GO | 2:4 (2:2) | ||
| 1st(1st leg): 26/08/2022 19:00 | 2nd (2nd leg): 31/08/2022 19:00 | Winner: Vila Nova - GO | ||||
