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| 1st(1st leg) | Violette AC | - | Austin FC | 3:0 (2:0) | ||
| 2nd (2nd leg) | Austin FC | - | Violette AC | 2:0 (0:0) | ||
| 1st(1st leg): 07/03/2023 23:00 | 2nd (2nd leg): 15/03/2023 00:00 | Winner: Violette AC | ||||
| 1st(1st leg) | Alianza | - | Philadelphia Union | 0:0 (0:0) | ||
| 2nd (2nd leg) | Philadelphia Union | - | Alianza | 4:0 (1:0) | ||
| 1st(1st leg): 08/03/2023 01:00 | 2nd (2nd leg): 15/03/2023 00:00 | Winner: Philadelphia Union | ||||
| 1st(1st leg) | UANL Tigres | - | Orlando City | 0:0 (0:0) | ||
| 2nd (2nd leg) | Orlando City | - | UANL Tigres | 1:1 (0:1) | ||
| 1st(1st leg): 08/03/2023 03:00 | 2nd (2nd leg): 16/03/2023 00:15 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Tauro FC | - | Club León | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club León | - | Tauro FC | 2:0 (2:0) | ||
| 1st(1st leg): 08/03/2023 23:00 | 2nd (2nd leg): 17/03/2023 00:00 | Winner: Club León | ||||
| 1st(1st leg) | Olimpia | - | Atlas Guadalajara | 4:1 (1:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Olimpia | 4:0 (1:0) | ||
| 1st(1st leg): 09/03/2023 01:00 | 2nd (2nd leg): 15/03/2023 02:15 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Vancouver Whitecaps | - | Real España | 5:0 (1:0) | ||
| 2nd (2nd leg) | Real España | - | Vancouver Whitecaps | 3:2 (0:0) | ||
| 1st(1st leg): 09/03/2023 03:00 | 2nd (2nd leg): 15/03/2023 22:00 | Winner: Vancouver Whitecaps | ||||
| 1st(1st leg) | Motagua | - | CF Pachuca | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Motagua | 1:1 (0:0) | ||
| 1st(1st leg): 10/03/2023 01:00 | 2nd (2nd leg): 17/03/2023 02:15 | Winner: Motagua | ||||
| 1st(1st leg) | LD Alajuelense | - | Los Angeles FC | 0:3 (0:0) | ||
| 2nd (2nd leg) | Los Angeles FC | - | LD Alajuelense | 1:2 (0:1) | ||
| 1st(1st leg): 10/03/2023 03:00 | 2nd (2nd leg): 16/03/2023 02:30 | Winner: Los Angeles FC | ||||
