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| 1st(1st leg) | CD Magallanes | - | Independiente Medellín | 1:1 (0:0) | ||
| 2nd (2nd leg) | Independiente Medellín | - | CD Magallanes | 2:0 (2:0) | ||
| 1st(1st leg): 08/03/2023 22:00 | 2nd (2nd leg): 16/03/2023 00:00 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Millonarios | - | Atlético Mineiro | 1:1 (1:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Millonarios | 3:1 (0:0) | ||
| 1st(1st leg): 09/03/2023 00:30 | 2nd (2nd leg): 16/03/2023 00:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Fortaleza | - | Cerro Porteño | 0:1 (0:1) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Fortaleza | 2:1 (1:0) | ||
| 1st(1st leg): 09/03/2023 22:00 | 2nd (2nd leg): 16/03/2023 22:00 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Huracán | - | Sporting Cristal | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sporting Cristal | - | Huracán | 1:0 (0:0) | ||
| 1st(1st leg): 10/03/2023 00:00 | 2nd (2nd leg): 17/03/2023 00:00 | Winner: Sporting Cristal | ||||
