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| 1st(1st leg) | Monagas | - | Defensor Sporting | 2:0 (0:0) | ||
| 2nd (2nd leg) | Defensor Sporting | - | Monagas | 0:2 (0:1) | ||
| 1st(1st leg): 05/02/2025 00:30 | 2nd (2nd leg): 12/02/2025 00:30 | Winner: Monagas | ||||
| 1st(1st leg) | Club Nacional | - | Alianza Lima | 1:1 (1:0) | ||
| 2nd (2nd leg) | Alianza Lima | - | Club Nacional | 3:1 (1:1) | ||
| 1st(1st leg): 06/02/2025 00:30 | 2nd (2nd leg): 13/02/2025 00:30 | Winner: Alianza Lima | ||||
| 1st(1st leg) | Blooming | - | El Nacional | 3:2 (3:1) | ||
| 2nd (2nd leg) | El Nacional | - | Blooming | 4:3 (0:1, 2:1) pso | ||
| 1st(1st leg): 07/02/2025 00:30 | 2nd (2nd leg): 14/02/2025 00:30 | Winner: El Nacional | ||||
