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| 1st(1st leg) | Fortaleza - CE | - | Vélez Sarsfield | -:- | ||
| 2nd (2nd leg) | Vélez Sarsfield | - | Fortaleza - CE | -:- | ||
| 1st(1st leg): 12/08/2025 23:00 | 2nd (2nd leg): 19/08/2025 23:00 | |||||
| 1st(1st leg) | Atlético Nacional | - | São Paulo FC | -:- | ||
| 2nd (2nd leg) | São Paulo FC | - | Atlético Nacional | -:- | ||
| 1st(1st leg): 13/08/2025 01:30 | 2nd (2nd leg): 20/08/2025 01:30 | |||||
| 1st(1st leg) | Peñarol | - | Racing Club | -:- | ||
| 2nd (2nd leg) | Racing Club | - | Peñarol | -:- | ||
| 1st(1st leg): 13/08/2025 01:30 | 2nd (2nd leg): 20/08/2025 01:30 | |||||
| 1st(1st leg) | Cerro Porteño | - | Estudiantes | -:- | ||
| 2nd (2nd leg) | Estudiantes | - | Cerro Porteño | -:- | ||
| 1st(1st leg): 13/08/2025 23:00 | 2nd (2nd leg): 20/08/2025 23:00 | |||||
| 1st(1st leg) | Flamengo RJ | - | Internacional | -:- | ||
| 2nd (2nd leg) | Internacional | - | Flamengo RJ | -:- | ||
| 1st(1st leg): 14/08/2025 01:30 | 2nd (2nd leg): 21/08/2025 01:30 | |||||
| 1st(1st leg) | Botafogo - RJ | - | LDU Quito | -:- | ||
| 2nd (2nd leg) | LDU Quito | - | Botafogo - RJ | -:- | ||
| 1st(1st leg): 14/08/2025 23:00 | 2nd (2nd leg): 21/08/2025 23:00 | |||||
| 1st(1st leg) | Universitario de Deportes | - | Palmeiras | -:- | ||
| 2nd (2nd leg) | Palmeiras | - | Universitario de Deportes | -:- | ||
| 1st(1st leg): 15/08/2025 01:30 | 2nd (2nd leg): 22/08/2025 01:30 | |||||
| 1st(1st leg) | Libertad | - | River Plate | -:- | ||
| 2nd (2nd leg) | River Plate | - | Libertad | -:- | ||
| 1st(1st leg): 15/08/2025 01:30 | 2nd (2nd leg): 22/08/2025 01:30 | |||||
