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| 01/10/2010 | 18:30 | Slavia Praha | - | Viktoria Plzeň | 0:1 (0:1) | |
| 02/10/2010 | 15:00 | 1. FK Příbram | - | Dynamo České Budějovice | 2:0 (0:0) | |
| 15:15 | FK Teplice | - | Slovan Liberec | 1:0 (1:0) | ||
| 17:00 | Baník Ostrava | - | 1. FC Slovácko | 2:1 (1:0) | ||
| 03/10/2010 | 13:30 | Zbrojovka Brno | - | FC Hradec Králové | 1:2 (1:1) | |
| 16:00 | FK Baumit Jablonec | - | FK Ústí nad Labem | 2:0 (1:0) | ||
| 16:00 | FK Mladá Boleslav | - | Bohemians 1905 | 3:2 (1:2) | ||
| 04/10/2010 | 17:00 | Sigma Olomouc | - | AC Sparta Praha | 0:1 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Viktoria Plzeň | 11 | 10 | 1 | 0 | 29:7 | 22 | 31 |
| 2 |
|
AC Sparta Praha | 11 | 7 | 1 | 3 | 18:7 | 11 | 22 |
| 3 |
|
Sigma Olomouc | 11 | 5 | 4 | 2 | 19:7 | 12 | 19 |
| 4 |
|
FK Mladá Boleslav | 11 | 5 | 4 | 2 | 18:12 | 6 | 19 |
| 5 |
|
FK Teplice | 11 | 5 | 3 | 3 | 14:13 | 1 | 18 |
| 6 |
|
1. FC Slovácko | 11 | 5 | 1 | 5 | 14:13 | 1 | 16 |
| 7 |
|
FK Baumit Jablonec | 11 | 4 | 2 | 5 | 14:13 | 1 | 14 |
| 8 |
|
FC Hradec Králové | 11 | 3 | 4 | 4 | 10:13 | -3 | 13 |
| 9 |
|
Slovan Liberec | 11 | 3 | 4 | 4 | 14:15 | -1 | 13 |
| 10 |
|
Baník Ostrava | 11 | 3 | 3 | 5 | 10:15 | -5 | 12 |
| 11 |
|
Dynamo České Budějovice | 11 | 2 | 6 | 3 | 8:13 | -5 | 12 |
| 12 |
|
1. FK Příbram | 11 | 3 | 3 | 5 | 6:9 | -3 | 12 |
| 13 |
|
Slavia Praha | 11 | 2 | 4 | 5 | 10:16 | -6 | 10 |
| 14 |
|
FK Ústí nad Labem | 11 | 2 | 4 | 5 | 9:22 | -13 | 10 |
| 15 |
|
Bohemians 1905 | 11 | 2 | 4 | 5 | 11:15 | -4 | 10 |
| 16 |
|
Zbrojovka Brno | 11 | 3 | 0 | 8 | 11:25 | -14 | 9 |
| Champions League Quali. | |
| Europa League | |
| Relegation |
