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| 1st(1st leg) | LDU Quito | - | Ñañas | 0:2 (0:1) | ||
| 2nd (2nd leg) | Ñañas | - | LDU Quito | 1:2 (1:0) | ||
| 1st(1st leg): 21/08/2021 21:00 | 2nd (2nd leg): 29/08/2021 21:00 | Winner: Ñañas | ||||
| 1st(1st leg) | Dragonas IDV | - | Deportivo Cuenca | 2:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo Cuenca | - | Dragonas IDV | 5:2 (4:2) | ||
| 1st(1st leg): 22/08/2021 23:00 | 2nd (2nd leg): 28/08/2021 16:00 | Winner: Deportivo Cuenca | ||||
