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| 1st(1st leg) | CF América | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF América | 2:2 (0:0) | ||
| 1st(1st leg): 27/11/2020 18:00 | 2nd (2nd leg): 30/11/2020 23:00 | Winner: CF América | ||||
| 1st(1st leg) | Pumas UNAM | - | CF Monterrey | 1:1 (0:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Pumas UNAM | 4:0 (1:0) | ||
| 1st(1st leg): 27/11/2020 21:45 | 2nd (2nd leg): 01/12/2020 03:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Gallos Blancos | - | Atlas Guadalajara | 1:2 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Gallos Blancos | 2:3 (2:1) | ||
| 1st(1st leg): 28/11/2020 01:00 | 2nd (2nd leg): 30/11/2020 16:00 | Winner: Gallos Blancos | ||||
| 1st(1st leg) | CF Pachuca | - | UANL Tigres | 1:2 (0:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | CF Pachuca | 4:1 (3:0) | ||
| 1st(1st leg): 28/11/2020 03:00 | 2nd (2nd leg): 01/12/2020 01:00 | Winner: UANL Tigres | ||||
