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| 1st(1st leg) | Atlas Guadalajara | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Atlas Guadalajara | 2:1 (0:0) | ||
| 1st(1st leg): 14/05/2021 23:00 | 2nd (2nd leg): 18/05/2021 03:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | CF Monterrey | - | UANL Tigres | 2:2 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | CF Monterrey | 4:1 (2:1) | ||
| 1st(1st leg): 15/05/2021 03:05 | 2nd (2nd leg): 18/05/2021 01:00 | Winner: UANL Tigres | ||||
