 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 07/05/2021 | 16:00 | CF América | - | UANL Tigres | 0:4 (0:2) | |
| 18:00 | Pumas UNAM | - | CF Monterrey | 1:2 (0:2) | ||
| 22:00 | Deportivo Toluca | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| 08/05/2021 | 00:30 | CF Pachuca | - | Atlas Guadalajara | 0:2 (0:1) | |
| 10/05/2021 | 22:00 | Atlas Guadalajara | - | CF Pachuca | 3:1 (1:0) | |
| 11/05/2021 | 00:00 | Deportivo Guadalajara | - | Deportivo Toluca | 3:0 (0:0) | |
| 02:00 | UANL Tigres | - | CF América | 2:0 (0:0) | ||
| 04:00 | CF Monterrey | - | Pumas UNAM | 2:1 (0:1) | ||
| Semi-finals | ||||||
| 14/05/2021 | 23:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:0 (0:0) | |
| 15/05/2021 | 03:05 | CF Monterrey | - | UANL Tigres | 2:2 (0:0) | |
| 18/05/2021 | 01:00 | UANL Tigres | - | CF Monterrey | 4:1 (2:1) | |
| 03:00 | Deportivo Guadalajara | - | Atlas Guadalajara | 2:1 (0:0) | ||
| Final | ||||||
| 25/05/2021 | 03:00 | Deportivo Guadalajara | - | UANL Tigres | 1:2 (0:1) | |
| 01/06/2021 | 01:00 | UANL Tigres | - | Deportivo Guadalajara | 5:3 (3:1) | |
