 |
 |
|
| 30/04/2021 | 18:45 | Cruz Azul | - | Gallos Blancos | 2:5 (0:1) | |
| 01/05/2021 | 16:00 | Mazatlán FC | - | Santos Laguna | 2:3 (2:2) | |
| 16:00 | CF Pachuca | - | Atlético San Luis | 4:1 (1:0) | ||
| 02/05/2021 | 16:00 | FC Juárez | - | Club León | 2:1 (2:1) | |
| 18:00 | Puebla FC | - | CF América | 1:0 (0:0) | ||
| 03/05/2021 | 22:00 | Deportivo Toluca | - | Pumas UNAM | 0:1 (0:1) | |
| 04/05/2021 | 01:00 | Deportivo Guadalajara | - | UANL Tigres | 3:4 (1:3) | |
| 03:00 | Club Tijuana | - | Club Necaxa | 3:0 (2:0) | ||
| 03:00 | CF Monterrey | - | Atlas Guadalajara | 3:1 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 17 | 12 | 4 | 1 | 39:12 | 27 | 40 |
| 2 |
|
Deportivo Guadalajara | 17 | 11 | 3 | 3 | 44:19 | 25 | 36 |
| 3 |
|
Atlas Guadalajara | 17 | 10 | 4 | 3 | 30:23 | 7 | 34 |
| 4 |
|
CF Monterrey | 17 | 10 | 3 | 4 | 40:22 | 18 | 33 |
| 5 |
|
Pumas UNAM | 17 | 9 | 5 | 3 | 24:17 | 7 | 32 |
| 6 |
|
CF Pachuca | 17 | 9 | 3 | 5 | 24:15 | 9 | 30 |
| 7 |
|
Deportivo Toluca | 17 | 8 | 5 | 4 | 17:14 | 3 | 29 |
| 8 |
|
CF América | 17 | 6 | 6 | 5 | 23:22 | 1 | 24 |
| 9 |
|
Cruz Azul | 17 | 6 | 4 | 7 | 21:26 | -5 | 22 |
| 10 |
|
Santos Laguna | 17 | 5 | 5 | 7 | 24:27 | -3 | 20 |
| 11 |
|
Gallos Blancos | 17 | 6 | 1 | 10 | 21:27 | -6 | 19 |
| 12 |
|
Club Tijuana | 17 | 5 | 3 | 9 | 17:20 | -3 | 18 |
| 13 |
|
Mazatlán FC | 17 | 4 | 6 | 7 | 16:25 | -9 | 18 |
| 14 |
|
Club León | 17 | 5 | 2 | 10 | 17:33 | -16 | 17 |
| 15 |
|
Club Necaxa | 17 | 4 | 4 | 9 | 14:29 | -15 | 16 |
| 16 |
|
Puebla FC | 17 | 3 | 4 | 10 | 14:24 | -10 | 13 |
| 17 |
|
FC Juárez | 17 | 3 | 3 | 11 | 15:28 | -13 | 12 |
| 18 |
|
Atlético San Luis | 17 | 2 | 5 | 10 | 19:36 | -17 | 11 |
| Playoffs |
