 |
 |
|
|
| 22/04/2021 | 23:00 | Gallos Blancos | - | Club Tijuana | 2:1 (1:1) | |
| 23/04/2021 | 22:00 | Club Necaxa | - | CF Pachuca | 1:0 (0:0) | |
| 24/04/2021 | 18:00 | Pumas UNAM | - | Atlas Guadalajara | 1:1 (1:0) | |
| 25/04/2021 | 18:00 | CF América | - | Cruz Azul | 2:1 (2:1) | |
| 26/04/2021 | 23:00 | Atlético San Luis | - | Deportivo Toluca | 1:2 (0:0) | |
| 23:00 | Deportivo Guadalajara | - | CF Monterrey | 5:0 (0:0) | ||
| 27/04/2021 | 01:00 | Club León | - | Puebla FC | 2:1 (1:1) | |
| 01:00 | Santos Laguna | - | FC Juárez | 3:0 (1:0) | ||
| 01:00 | UANL Tigres | - | Mazatlán FC | 2:2 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 16 | 11 | 4 | 1 | 35:9 | 26 | 37 |
| 2 |
|
Deportivo Guadalajara | 16 | 11 | 3 | 2 | 41:15 | 26 | 36 |
| 3 |
|
Atlas Guadalajara | 16 | 10 | 4 | 2 | 29:20 | 9 | 34 |
| 4 |
|
CF Monterrey | 16 | 9 | 3 | 4 | 37:21 | 16 | 30 |
| 5 |
|
Pumas UNAM | 16 | 8 | 5 | 3 | 23:17 | 6 | 29 |
| 6 |
|
Deportivo Toluca | 16 | 8 | 5 | 3 | 17:13 | 4 | 29 |
| 7 |
|
CF Pachuca | 16 | 8 | 3 | 5 | 20:14 | 6 | 27 |
| 8 |
|
CF América | 16 | 6 | 6 | 4 | 23:21 | 2 | 24 |
| 9 |
|
Cruz Azul | 16 | 6 | 4 | 6 | 19:21 | -2 | 22 |
| 10 |
|
Mazatlán FC | 16 | 4 | 6 | 6 | 14:22 | -8 | 18 |
| 11 |
|
Santos Laguna | 16 | 4 | 5 | 7 | 21:25 | -4 | 17 |
| 12 |
|
Club León | 16 | 5 | 2 | 9 | 16:31 | -15 | 17 |
| 13 |
|
Gallos Blancos | 16 | 5 | 1 | 10 | 16:25 | -9 | 16 |
| 14 |
|
Club Necaxa | 16 | 4 | 4 | 8 | 14:26 | -12 | 16 |
| 15 |
|
Club Tijuana | 16 | 4 | 3 | 9 | 14:20 | -6 | 15 |
| 16 |
|
Atlético San Luis | 16 | 2 | 5 | 9 | 18:32 | -14 | 11 |
| 17 |
|
Puebla FC | 16 | 2 | 4 | 10 | 13:24 | -11 | 10 |
| 18 |
|
FC Juárez | 16 | 2 | 3 | 11 | 13:27 | -14 | 9 |
| Playoffs |
