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| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 2:0 (2:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 2:1 (0:0) | ||
| 1st(1st leg): 14/05/2022 00:05 | 2nd (2nd leg): 17/05/2022 03:05 | Winner: CF Pachuca | ||||
| 1st(1st leg) | UANL Tigres | - | Deportivo Guadalajara | 2:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | UANL Tigres | 2:0 (1:0) | ||
| 1st(1st leg): 14/05/2022 02:05 | 2nd (2nd leg): 17/05/2022 01:00 | |||||
