 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 05/05/2022 | 23:00 | Atlas Guadalajara | - | UANL Tigres | 0:7 (0:4) | |
| 06/05/2022 | 01:00 | CF Pachuca | - | CF América | 2:1 (1:1) | |
| 07/05/2022 | 00:00 | Pumas UNAM | - | Deportivo Guadalajara | 2:2 (0:1) | |
| 03:00 | Club Tijuana | - | CF Monterrey | 0:1 (0:0) | ||
| 08/05/2022 | 18:00 | CF América | - | CF Pachuca | 1:2 (0:1) | |
| 09/05/2022 | 03:00 | UANL Tigres | - | Atlas Guadalajara | 2:1 (2:1) | |
| 10/05/2022 | 01:00 | Deportivo Guadalajara | - | Pumas UNAM | 3:2 (1:2) | |
| 03:00 | CF Monterrey | - | Club Tijuana | 2:1 (2:0) | ||
| Semi-finals | ||||||
| 14/05/2022 | 00:05 | CF Pachuca | - | CF Monterrey | 2:0 (2:0) | |
| 02:05 | UANL Tigres | - | Deportivo Guadalajara | 2:0 (0:0) | ||
| 17/05/2022 | 01:00 | Deportivo Guadalajara | - | UANL Tigres | 2:0 (1:0) | |
| 03:05 | CF Monterrey | - | CF Pachuca | 2:1 (0:0) | ||
| Final | ||||||
| 21/05/2022 | 03:00 | CF Pachuca | - | Deportivo Guadalajara | 2:4 (1:0) | |
| 24/05/2022 | 02:05 | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | |
