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| 1st(1st leg) | CF Pachuca | - | Atlas Guadalajara | 2:2 (1:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | CF Pachuca | 3:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 02/12/2021 00:00 | 2nd (2nd leg): 04/12/2021 23:00 | Winner: CF Pachuca | ||||
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| 1st(1st leg) | CF Pachuca | - | Atlas Guadalajara | 2:2 (1:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | CF Pachuca | 3:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 02/12/2021 00:00 | 2nd (2nd leg): 04/12/2021 23:00 | Winner: CF Pachuca | ||||
