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| 13/11/2021 | 12:15 | SBV Excelsior | - | Willem II | 2:4 | |
| 13:30 | De Graafschap | - | Koninklijke HFC | 1:3 | ||
| 14:00 | VVV-Venlo | - | Alphense Boys | 0:1 | ||
| 15:00 | Almere City FC | - | FC Dordrecht | 3:0 |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Willem II | 10 | 9 | 0 | 1 | 36:16 | 20 | 27 |
| 2 |
|
De Graafschap | 10 | 5 | 2 | 3 | 35:14 | 21 | 17 |
| 3 |
|
Almere City FC | 10 | 4 | 2 | 4 | 29:20 | 9 | 14 |
| 4 |
|
SBV Excelsior | 10 | 4 | 2 | 4 | 27:22 | 5 | 14 |
| 5 |
|
VVV-Venlo | 10 | 3 | 4 | 3 | 15:17 | -2 | 13 |
| 6 |
|
Alphense Boys | 10 | 3 | 2 | 5 | 17:36 | -19 | 11 |
| 7 |
|
Koninklijke HFC | 10 | 2 | 4 | 4 | 19:26 | -7 | 10 |
| 8 |
|
FC Dordrecht | 10 | 1 | 2 | 7 | 11:38 | -27 | 5 |
| Promotion | |
| Relegation |
