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| 20/11/2021 | 09:30 | Willem II | - | FC Dordrecht | 7:1 | |
| 11:45 | Alphense Boys | - | Koninklijke HFC | 1:0 | ||
| 12:15 | SBV Excelsior | - | De Graafschap | 1:2 | ||
| 14:00 | VVV-Venlo | - | Almere City FC | 3:4 |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Willem II | 11 | 10 | 0 | 1 | 43:17 | 26 | 30 |
| 2 |
|
De Graafschap | 11 | 6 | 2 | 3 | 37:15 | 22 | 20 |
| 3 |
|
Almere City FC | 11 | 5 | 2 | 4 | 33:23 | 10 | 17 |
| 4 |
|
SBV Excelsior | 11 | 4 | 2 | 5 | 28:24 | 4 | 14 |
| 5 |
|
Alphense Boys | 11 | 4 | 2 | 5 | 18:36 | -18 | 14 |
| 6 |
|
VVV-Venlo | 11 | 3 | 4 | 4 | 18:21 | -3 | 13 |
| 7 |
|
Koninklijke HFC | 11 | 2 | 4 | 5 | 19:27 | -8 | 10 |
| 8 |
|
FC Dordrecht | 11 | 1 | 2 | 8 | 12:45 | -33 | 5 |
| Promotion | |
| Relegation |
