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| 25/09/2018 | 14:00 | FC Voluntari | - | FC Botoşani | 2:1 (2:0) | |
| 14:30 | FK Csikszereda | - | ACS Viitorul Târgu Jiu | 2:1 (1:0) | ||
| 16:45 | Sportul Snagov | - | CS Universitatea Craiova | 0:2 (0:1) | ||
| 17:00 | ASU Poli Timișoara | - | Sepsi OSK | 2:4 (1:1, 1:1, 1:1) pso | ||
| 19:30 | Dacia Unirea Brăila | - | Dinamo Bucureşti | 1:3 (1:2) | ||
| 26/09/2018 | 14:00 | UTA Arad | - | FC Politehnica Iași | 3:5 (1:1, 2:2, 3:3) pso | |
| 14:30 | Sporting Lieşti | - | CS Mioveni | 0:3 (0:1) | ||
| 14:30 | CSM Slatina | - | FC Dunărea Călărași | 0:2 (0:2) | ||
| 14:30 | Academica Clinceni | - | FC Hermannstadt | 0:2 (0:0) | ||
| 14:30 | Progresul Bucuresti | - | Universitatea Cluj | 0:1 (0:1) | ||
| 16:45 | Concordia Chiajna | - | FC Viitorul Constanța | 0:3 (0:1) | ||
| 19:30 | Chindia Târgoviște | - | CFR Cluj | 0:1 (0:1) | ||
| 27/09/2018 | 14:00 | Luceafărul Oradea | - | Astra Giurgiu | 1:5 (0:0) | |
| 14:30 | Bucovina Rădăuți | - | Gaz Metan Mediaş | 7:8 (0:0, 1:1, 1:1) pso | ||
| 16:45 | Rapid Bucureşti | - | Turris-Oltul | 0:2 (0:0) | ||
| 19:30 | FC Unirea Alba Iulia | - | FCSB | 0:1 (0:0) |
