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| 1st(1st leg) | FC Voluntari | - | Argeș Pitești | 2:0 (2:0) | ||
| 2nd (2nd leg) | Argeș Pitești | - | FC Voluntari | 0:1 (0:0) | ||
| 1st(1st leg): 19/04/2022 18:00 | 2nd (2nd leg): 11/05/2022 17:30 | Winner: FC Voluntari | ||||
| 1st(1st leg) | Sepsi OSK | - | CS Universitatea Craiova | 2:1 (1:0) | ||
| 2nd (2nd leg) | CS Universitatea Craiova | - | Sepsi OSK | 0:1 (0:0) | ||
| 1st(1st leg): 20/04/2022 17:30 | 2nd (2nd leg): 12/05/2022 17:30 | Winner: Sepsi OSK | ||||
