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| 08/01/2022 | 10:30 | Bandırmaspor | - | Denizlispor | 3:4 (3:0) | |
| 10:30 | Ümraniyespor | - | Kocaelispor | 1:0 (0:0) | ||
| 13:00 | Adanaspor | - | Bursaspor | 3:1 (0:0) | ||
| 16:00 | MKE Ankaragücü | - | Tuzlaspor | 1:0 (0:0) | ||
| 09/01/2022 | 10:30 | BB Erzurumspor | - | Menemen Belediyespor | 1:1 (1:0) | |
| 10:30 | Manisa FK | - | İstanbulspor AŞ | 1:2 (1:1) | ||
| 13:00 | Boluspor | - | Balıkesirspor | 1:0 (1:0) | ||
| 16:00 | Eyüpspor | - | Gençlerbirliği | 1:0 (0:0) | ||
| 10/01/2022 | 17:00 | Altınordu FK | - | Keçiörengücü | 2:3 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 19 | 13 | 3 | 3 | 35:15 | 20 | 42 |
| 2 |
|
MKE Ankaragücü | 19 | 12 | 3 | 4 | 30:14 | 16 | 39 |
| 3 |
|
BB Erzurumspor | 19 | 11 | 4 | 4 | 33:22 | 11 | 37 |
| 4 |
|
Eyüpspor | 19 | 10 | 5 | 4 | 30:22 | 8 | 35 |
| 5 |
|
Bandırmaspor | 19 | 10 | 2 | 7 | 31:19 | 12 | 32 |
| 6 |
|
İstanbulspor AŞ | 19 | 9 | 3 | 7 | 29:25 | 4 | 30 |
| 7 |
|
Adanaspor | 19 | 8 | 5 | 6 | 23:20 | 3 | 29 |
| 8 |
|
Samsunspor | 18 | 7 | 6 | 5 | 26:23 | 3 | 27 |
| 9 |
|
Gençlerbirliği | 19 | 8 | 2 | 9 | 23:26 | -3 | 26 |
| 10 |
|
Boluspor | 19 | 6 | 6 | 7 | 21:21 | 0 | 24 |
| 11 |
|
Tuzlaspor | 19 | 6 | 6 | 7 | 19:19 | 0 | 24 |
| 12 |
|
Kocaelispor | 19 | 7 | 3 | 9 | 19:23 | -4 | 24 |
| 13 |
|
Keçiörengücü | 19 | 6 | 4 | 9 | 27:32 | -5 | 22 |
| 14 |
|
Manisa FK | 19 | 6 | 4 | 9 | 21:26 | -5 | 22 |
| 15 |
|
Menemen Belediyespor | 19 | 5 | 7 | 7 | 22:32 | -10 | 22 |
| 16 |
|
Altınordu FK | 19 | 7 | 1 | 11 | 26:38 | -12 | 22 |
| 17 |
|
Bursaspor | 19 | 5 | 4 | 10 | 23:31 | -8 | 19 |
| 18 |
|
Denizlispor | 19 | 5 | 4 | 10 | 19:29 | -10 | 19 |
| 19 |
|
Balıkesirspor | 19 | 2 | 2 | 15 | 14:34 | -20 | 8 |
| Promotion | |
| Playoffs | |
| Relegation |
