Copa Libertadores   M. W D L goals
  at home 2 2 0 0 7 : 2
  Away 2 0 0 2 0 : 4
  4 2 0 2 7 : 6
Copa Sudamericana   M. W D L goals
  at home 1 1 0 0 2 : 1
  Away 1 0 0 0 0 : 0
  2 1 0 0 2 : 1
overall   M. W D L goals
  at home 3 3 0 0 9 : 3
  Away 3 0 0 2 0 : 4
  Neutral Place 0 0 0 0 0 : 0
  6 3 0 2 9 : 7
Copa Libertadores
2020 Group 4 LDU Quito - São Paulo FC 4:2 (3:0)
2020 Group 4 São Paulo FC - LDU Quito 3:0 (2:0)
2004 Group 4 São Paulo FC - LDU Quito 1:0 (0:0)
2004 Group 4 LDU Quito - São Paulo FC 3:0 (2:0)
Copa Sudamericana
2023 Quarter-finals São Paulo FC - LDU Quito 4:5 (0:0, 1:0) pso
2023 Quarter-finals LDU Quito - São Paulo FC 2:1 (2:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking