Primera División   M. W D L goals
  at home 11 9 1 1 27 : 8
  Away 11 3 3 5 16 : 19
  22 12 4 6 43 : 27
Copa MX   M. W D L goals
  at home 1 1 0 0 3 : 0
  Away 1 0 1 0 0 : 0
  2 1 1 0 3 : 0
overall   M. W D L goals
  at home 12 10 1 1 30 : 8
  Away 12 3 4 5 16 : 19
  Neutral Place 0 0 0 0 0 : 0
  24 13 5 6 46 : 27
Primera División
2023/2024 Apertura 17. Round Atlético San Luis - Santos Laguna 0:2 (0:2)
2022/2023 Clausura 8. Round Atlético San Luis - Santos Laguna 1:1 (1:0)
2022/2023 Apertura 11. Round Santos Laguna - Atlético San Luis 4:1 (1:0)
2021/2022 Clausura 17. Round Atlético San Luis - Santos Laguna 1:3 (0:0)
2021/2022 Apertura Playoffs Recalificación Santos Laguna - Atlético San Luis 2:0 (0:0)
2021/2022 Apertura 17. Round Santos Laguna - Atlético San Luis 0:0 (0:0)
2020/2021 Clausura 7. Round Atlético San Luis - Santos Laguna 1:0 (1:0)
2020/2021 Apertura 15. Round Santos Laguna - Atlético San Luis 2:1 (1:1)
2019/2020 Apertura 10. Round Atlético San Luis - Santos Laguna 2:3 (2:2)
2007/2008 Clausura 3. Round Veracruz (old) - Santos Laguna 1:1 (1:0)
2007/2008 Apertura 3. Round Santos Laguna - Veracruz (old) 2:0 (2:0)
2006/2007 Clausura 12. Round Santos Laguna - Veracruz (old) 1:0 (1:0)
2006/2007 Apertura 12. Round Veracruz (old) - Santos Laguna 5:1 (1:0)
2005/2006 Clausura 9. Round Santos Laguna - Veracruz (old) 0:2 (0:0)
2005/2006 Apertura 9. Round Veracruz (old) - Santos Laguna 2:2 (2:1)
2004/2005 Clausura 15. Round Santos Laguna - Veracruz (old) 4:1 (1:0)
2004/2005 Apertura 15. Round Veracruz (old) - Santos Laguna 3:2 (0:2)
2003/2004 Clausura 6. Round Veracruz (old) - Santos Laguna 2:1 (1:1)
2003/2004 Apertura 6. Round Santos Laguna - Veracruz (old) 3:0 (0:0)
2002/2003 Clausura 17. Round Veracruz (old) - Santos Laguna 1:0 (0:0)
2002/2003 Apertura 17. Round Santos Laguna - Veracruz (old) 4:2 (2:0)
2001/2002 Verano 19. Round Santos Laguna - Veracruz (old) 5:1 (2:0)
Copa MX
2014/2015 Clausura Group 1 Santos Laguna - Atlético San Luis 3:0
2014/2015 Clausura Group 1 Atlético San Luis - Santos Laguna 0:0

For games that were decided on penalties the score after 120 minutes will be included in the ranking