 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 14/05/2022 | 16:00 | Pumas UNAM | - | Club Tijuana | 6:5 pso | |
| 17:15 | Deportivo Guadalajara | - | CF América | 3:2 | ||
| 17:30 | Club Necaxa | - | UANL Tigres | 6:5 pso | ||
| 21:45 | Atlas Guadalajara | - | CF Pachuca | 2:3 | ||
| Semi-finals | ||||||
| 21/05/2022 | 16:00 | Pumas UNAM | - | CF Pachuca | 0:3 | |
| 17:15 | Deportivo Guadalajara | - | Club Necaxa | 3:4 pso | ||
| Final | ||||||
| 25/05/2022 | 15:00 | CF Pachuca | - | Club Necaxa | 1:0 | |
| 28/05/2022 | 18:30 | Club Necaxa | - | CF Pachuca | 1:1 | |
