1. Round
22/08/2021 FC Istres FC Istres - Pieve di Lota Pieve di Lota -:-
22/08/2021 Toulouse FC Toulouse FC - AS Monaco AS Monaco -:-
22/08/2021 OGC Nice OGC Nice - US Colomiers US Colomiers -:-
22/08/2021 AS Cannes AS Cannes - AC Ajaccio AC Ajaccio -:-
22/08/2021 Olympique Marseille Olympique Marseille - Nîmes Olympique Nîmes Olympique -:-
22/08/2021 SC Toulon SC Toulon - Montpellier HSC Montpellier HSC -:-
22/08/2021 AS Béziers AS Béziers - AS Saint-Étienne AS Saint-Étienne -:-
2. Round
29/08/2021 AS Monaco AS Monaco - FC Istres FC Istres -:-
29/08/2021 US Colomiers US Colomiers - Toulouse FC Toulouse FC -:-
29/08/2021 AC Ajaccio AC Ajaccio - OGC Nice OGC Nice -:-
29/08/2021 Nîmes Olympique Nîmes Olympique - AS Cannes AS Cannes -:-
29/08/2021 Montpellier HSC Montpellier HSC - Olympique Marseille Olympique Marseille -:-
29/08/2021 AS Béziers AS Béziers - SC Toulon SC Toulon -:-
29/08/2021 AS Saint-Étienne AS Saint-Étienne - Pieve di Lota Pieve di Lota -:-