Uruguayan captain Diego Godin looks set to miss his country's 2018 World Cup qualifiers against Brazil and Peru later this month and is a doubt for Atletico Madrid's Champions League quarter-final due to a hamstring injury.

Godin suffered a hamstring problem in his right leg, Atletico confirmed on Wednesday, after limping off as the Spanish side progressed to the last eight of the Champions League on penalties against PSV Eindhoven on Tuesday.

According to Spanish press reports, Godin is expected to be sidelined for at least three weeks.

That would rule the 30-year-old out of Uruguay's visit to Brazil on March 25 and meeting with Peru in Montevideo on March 29.

Uruguay have made a positive start to their qualifying campaign with three wins from their first four games and will be able to call upon Luis Suarez for the first time since the 2014 World Cup for a competitive fixture after his nine-match international ban for biting Giorgio Chiellini.

Godin also looks set to miss Atletico's La Liga clashes with Sporting Gijon and Real Betis.

However, of greater concern for coach Diego Simeone will be whether the inspirational central defender will be fit for the first leg of Atletico's quarter-final on April 5 or 6.

Simeone's men will find out who they will face in the last eight on Friday.

Atletico sit eight points adrift of Barcelona in second in La Liga with nine games to play.