| 17. Round | 20/01/2008 | Iraklis Saloniki | - | PAOK Saloniki | 1:0 | ||||
| 18. Round | 27/01/2008 | Iraklis Saloniki | - | Asteras Tripolis | 0:0 | ||||
| 19. Round | 03/02/2008 | Veria FC | - | Iraklis Saloniki | 1:2 | ||||
| 21. Round | 20/02/2008 | Levadiakos | - | Iraklis Saloniki | 3:0 | ||||
| 22. Round | 24/02/2008 | Iraklis Saloniki | - | AEK Athen | 0:1 | ||||
| 24. Round | 09/03/2008 | Iraklis Saloniki | - | Skoda Xanthi | 1:1 | ||||
| 25. Round | 16/03/2008 | Iraklis Saloniki | - | Panionios GSS | 1:0 |  |
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| 26. Round | 22/03/2008 | Panathinaikos | - | Iraklis Saloniki | 1:1 | |
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| 27. Round | 30/03/2008 | Iraklis Saloniki | - | OFI Heraklion | 1:0 | |
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| 28. Round | 06/04/2008 | Aris Saloniki | - | Iraklis Saloniki | 2:2 | ||||
| 29. Round | 13/04/2008 | Iraklis Saloniki | - | Apollon Kalamarias | 5:2 | |
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| 30. Round | 20/04/2008 | Olympiakos Piraeus | - | Iraklis Saloniki | 3:1 |
Spain