| 1. Round | 29/08/2021 | Lille OSC [Youth B] | - | Stade de Reims [Youth B] | 2:1 | ||||
| 2. Round | 04/09/2021 | Lille OSC [Youth B] | - | Entente Feignies Aulnoye [Youth B] | 6:0 | ||||
| 3. Round | 12/09/2021 | Paris 13 Atletico [Youth B] | - | Lille OSC [Youth B] | 0:1 | ||||
| 4. Round | 19/09/2021 | Lille OSC [Youth B] | - | JA Drancy [Youth B] | 2:0 | ||||
| 7. Round | 10/10/2021 | Amiens SC [Youth B] | - | Lille OSC [Youth B] | 3:2 | ||||
| 9. Round | 23/10/2021 | Valenciennes FC [Youth B] | - | Lille OSC [Youth B] | 1:1 | ||||
| 10. Round | 14/11/2021 | Lille OSC [Youth B] | - | USL Dunkerque [Youth B] | 4:0 | ||||
| 11. Round | 21/11/2021 | US Torcy [Youth B] | - | Lille OSC [Youth B] | 2:2 | ||||
| 12. Round | 28/11/2021 | Lille OSC [Youth B] | - | Montfermeil FC [Youth B] | 5:3 |
France
Morocco