| 1. Round | 29/08/2021 | Lille OSC [Youth B] | - | Stade de Reims [Youth B] | 2:1 | ||||
| 2. Round | 04/09/2021 | Lille OSC [Youth B] | - | Entente Feignies Aulnoye [Youth B] | 6:0 |  |
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| 3. Round | 12/09/2021 | Paris 13 Atletico [Youth B] | - | Lille OSC [Youth B] | 0:1 | ||||
| 5. Round | 25/09/2021 | ESTAC Troyes [Youth B] | - | Lille OSC [Youth B] | 0:1 | ||||
| 6. Round | 03/10/2021 | Lille OSC [Youth B] | - | AC Boulogne-Billancourt [Youth B] | 4:0 | |
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| 7. Round | 10/10/2021 | Amiens SC [Youth B] | - | Lille OSC [Youth B] | 3:2 | |
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| 8. Round | 17/10/2021 | Lille OSC [Youth B] | - | US Boulogne [Youth B] | 4:0 | ||||
| 9. Round | 23/10/2021 | Valenciennes FC [Youth B] | - | Lille OSC [Youth B] | 1:1 | |
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| 12. Round | 28/11/2021 | Lille OSC [Youth B] | - | Montfermeil FC [Youth B] | 5:3 | |
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| 13. Round | 05/12/2021 | RC Lens [Youth B] | - | Lille OSC [Youth B] | 2:2 | |
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| 19. Round | 13/03/2022 | Lille OSC [Youth B] | - | Amiens SC [Youth B] | 4:1 | ||||
| 24. Round | 17/04/2022 | Montfermeil FC [Youth B] | - | Lille OSC [Youth B] | 1:1 | ||||
| 25. Round | 01/05/2022 | Lille OSC [Youth B] | - | RC Lens [Youth B] | 3:1 | |
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| 26. Round | 15/05/2022 | Stade de Reims [Youth B] | - | Lille OSC [Youth B] | 1:4 | |
France
Algeria