| 4. Round | 28/08/2021 | Montpellier HSC B | - | US Colomiers | 1:2 | ||||
| 5. Round | 04/09/2021 | US Colomiers | - | FC Chamalières | 2:0 | ||||
| 6. Round | 11/09/2021 | Andrézieux-Bouthéon FC | - | US Colomiers | 0:1 | ||||
| 7. Round | 18/09/2021 | US Colomiers | - | Bergerac Périgord FC | 0:1 | ||||
| 10. Round | 23/10/2021 | US Colomiers | - | Angoulême CFC | 3:3 | ||||
| 17. Round | 05/02/2022 | Vendée Les Herbiers | - | US Colomiers | 1:3 | ||||
| 18. Round | 12/02/2022 | US Colomiers | - | Montpellier HSC B | 1:1 | ||||
| 19. Round | 19/02/2022 | FC Chamalières | - | US Colomiers | 2:0 | ||||
| 20. Round | 05/03/2022 | US Colomiers | - | Andrézieux-Bouthéon FC | 3:3 | ||||
| 21. Round | 12/03/2022 | Bergerac Périgord FC | - | US Colomiers | 1:0 | ||||
| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 | ||||
| 23. Round | 26/03/2022 | US Colomiers | - | Canet Roussillon | 2:3 | ||||
| 24. Round | 09/04/2022 | Angoulême CFC | - | US Colomiers | 0:2 | ||||
| 27. Round | 30/04/2022 | US Colomiers | - | AS Béziers | 1:3 | ||||
| 28. Round | 14/05/2022 | Stade Montois | - | US Colomiers | 0:1 | ||||
| 30. Round | 28/05/2022 | Le Puy Foot 43 | - | US Colomiers | 2:1 |
France
Spain