| 2. Round | 14/08/2021 | US Saint-Malo | - | Blois Foot 41 | 1:2 | ||||
| 3. Round | 21/08/2021 | FC Lorient B | - | US Saint-Malo | 2:0 | ||||
| 4. Round | 28/08/2021 | US Saint-Malo | - | EA Guingamp B | 0:2 | ||||
| 6. Round | 11/09/2021 | US Saint-Malo | - | C'Chartres Football | 2:1 | ||||
| 7. Round | 18/09/2021 | Châteaubriant Voltigeurs | - | US Saint-Malo | 4:0 |  |
|||
| 8. Round | 25/09/2021 | US Saint-Malo | - | Vannes OC | 2:2 | ||||
| 9. Round | 09/10/2021 | US Granvillaise | - | US Saint-Malo | 1:0 | ||||
| 16. Round | 22/01/2022 | Blois Foot 41 | - | US Saint-Malo | 1:0 | ||||
| 19. Round | 19/02/2022 | US Saint-Malo | - | AS Poissy | 2:0 | ||||
| 20. Round | 05/03/2022 | C'Chartres Football | - | US Saint-Malo | 2:1 | ||||
| 28. Round | 14/05/2022 | US Saint-Malo | - | SM Caen B | 1:0 | ||||
| 29. Round | 21/05/2022 | Stade Plabennec | - | US Saint-Malo | 0:6 |
France