| 3. Round | 24/01/2022 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:0 | ||||
| 8. Round | 01/03/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:0 | ||||
| 9. Round | 05/03/2022 | Mazatlán FC [Women] | - | Club Necaxa [Women] | 2:1 | ||||
| 10. Round | 15/03/2022 | CF Monterrey [Women] | - | Club Necaxa [Women] | 5:2 | ||||
| 11. Round | 17/03/2022 | Club Necaxa [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
| 12. Round | 20/03/2022 | Gallos Blancos [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 13. Round | 29/03/2022 | Club Tijuana [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 14. Round | 31/03/2022 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 1:2 | ||||
| 17. Round | 01/05/2022 | CF Pachuca [Women] | - | Club Necaxa [Women] | 1:1 |
Mexico