| 4. Round | 06/09/2021 | SD Huesca | - | Real Oviedo | 1:2 | ||||
| 8. Round | 02/10/2021 | Real Zaragoza | - | Real Oviedo | 0:0 | ||||
| 10. Round | 17/10/2021 | Real Sociedad B | - | Real Oviedo | 1:1 | ||||
| 12. Round | 24/10/2021 | SD Ponferradina | - | Real Oviedo | 1:2 | ||||
| 17. Round | 20/11/2021 | Real Oviedo | - | SD Amorebieta | 2:0 | ||||
| 20. Round | 12/12/2021 | Real Valladolid | - | Real Oviedo | 2:1 |
Spain