| 1. Round | 28/08/2021 | FC Barcelona B | - | Algeciras CF | 1:1 |  |
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| 3. Round | 12/09/2021 | FC Barcelona B | - | UE Costa Brava | 0:0 | ||||
| 14. Round | 27/11/2021 | FC Barcelona B | - | San Fernando CD | 0:2 | ||||
| 15. Round | 05/12/2021 | Villarreal CF B | - | FC Barcelona B | 3:0 | |
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| 18. Round | 09/01/2022 | FC Barcelona B | - | Real Betis B | 1:2 | ||||
| 20. Round | 25/01/2022 | UE Costa Brava | - | FC Barcelona B | 2:2 | ||||
| 21. Round | 29/01/2022 | FC Barcelona B | - | Real Madrid Castilla | 2:2 | ||||
| 29. Round | 27/03/2022 | Real Betis B | - | FC Barcelona B | 1:2 | ||||
| 30. Round | 03/04/2022 | RB Linense | - | FC Barcelona B | 1:2 | |
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| 31. Round | 09/04/2022 | FC Barcelona B | - | Villarreal CF B | 2:1 | ||||
| 32. Round | 17/04/2022 | Atlético Baleares | - | FC Barcelona B | 6:2 | ||||
| 33. Round | 23/04/2022 | FC Barcelona B | - | Atlético Sanluqueño CF | 5:0 | ||||
| 34. Round | 30/04/2022 | San Fernando CD | - | FC Barcelona B | 0:2 | |
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| 35. Round | 07/05/2022 | FC Barcelona B | - | CE Sabadell | 0:2 | ||||
| 37. Round | 21/05/2022 | FC Barcelona B | - | CD Castellón | 5:0 |
Spain
Dom. Republic 
