| 1. Round | 13/02/2022 | Gimnasia de Jujuy | - | Brown de Adrogué | 3:3 |  |
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| 2. Round | 19/02/2022 | Chacarita Juniors | - | Gimnasia de Jujuy | 0:0 | ||||
| 3. Round | 26/02/2022 | Gimnasia de Jujuy | - | Guillermo Brown | 3:1 | ||||
| 4. Round | 06/03/2022 | Atlético Rafaela | - | Gimnasia de Jujuy | 3:0 | ||||
| 5. Round | 13/03/2022 | Gimnasia de Jujuy | - | Ramón Santamarina | 1:0 | ||||
| 6. Round | 19/03/2022 | Estudiantes de Caseros | - | Gimnasia de Jujuy | 1:0 | ||||
| 7. Round | 24/03/2022 | Gimnasia de Jujuy | - | Atlanta | 1:1 | ||||
| 8. Round | 27/03/2022 | San Martín de San Juan | - | Gimnasia de Jujuy | 3:0 | ||||
| 9. Round | 02/04/2022 | Gimnasia de Jujuy | - | Chaco For Ever | 1:1 | |
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| 10. Round | 10/04/2022 | San Telmo | - | Gimnasia de Jujuy | 0:0 | ||||
| 11. Round | 17/04/2022 | Gimnasia de Jujuy | - | Gimnasia de Mendoza | 0:3 | ||||
| 12. Round | 24/04/2022 | All Boys | - | Gimnasia de Jujuy | 2:0 | ||||
| 13. Round | 30/04/2022 | Gimnasia de Jujuy | - | Güemes de SdE | 0:2 |
Argentina