| 14. Round | 05/12/2021 | UD Alzira | - | CS Puertollano CF | 2:1 | ||||
| 15. Round | 12/12/2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 17. Round | 09/01/2022 | Águilas FC | - | CS Puertollano CF | 1:0 | ||||
| 24. Round | 06/03/2022 | CF La Nucía | - | CS Puertollano CF | 3:2 | ||||
| 29. Round | 10/04/2022 | CS Puertollano CF | - | Mar Menor CF | 4:0 |
Spain