| 1. Round | 11/06/2022 | Cañuelas | - | Villa San Carlos | 0:0 | ||||
| 2. Round | 18/06/2022 | Villa San Carlos | - | Comunicaciones de Buenos Aires | 1:1 | ||||
| 3. Round | 26/06/2022 | CA Los Andes | - | Villa San Carlos | 0:3 |  |
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| 4. Round | 03/07/2022 | Villa San Carlos | - | Ituzaingó | 1:2 |  |
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| 5. Round | 11/07/2022 | Fénix | - | Villa San Carlos | 1:1 | |
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| 6. Round | 17/07/2022 | Villa San Carlos | - | Atlético San Miguel | 0:2 | ||||
| 7. Round | 23/07/2022 | Armenio | - | Villa San Carlos | 1:1 | ||||
| 8. Round | 31/07/2022 | Villa San Carlos | - | Dock Sud | 0:1 | ||||
| 9. Round | 06/08/2022 | UAI Urquiza | - | Villa San Carlos | 1:0 | ||||
| 11. Round | 20/08/2022 | Villa San Carlos | - | Defensores Unidos de Zárate | 1:0 | |
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| 13. Round | 04/09/2022 | Villa San Carlos | - | Deportivo Merlo | 1:0 | ||||
| 14. Round | 10/09/2022 | Colegiales de Munro | - | Villa San Carlos | 4:0 | |
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| 15. Round | 18/09/2022 | Villa San Carlos | - | Acassuso | 2:0 | |
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| 16. Round | 25/09/2022 | Argentino de Quilmes | - | Villa San Carlos | 1:1 | ||||
| 17. Round | 02/10/2022 | Villa San Carlos | - | Justo José de Urquiza | 2:1 |
Argentina