| 4. Round | 26/02/2022 | Argentinos Juniors II | - | San Lorenzo II | 2:0 |  |
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| 7. Round | 21/03/2022 | San Lorenzo II | - | Huracán II | 0:0 | ||||
| 8. Round | 04/04/2022 | San Lorenzo II | - | Atlético Tucumán II | 1:1 | ||||
| 10. Round | 15/04/2022 | San Lorenzo II | - | Platense II | 1:1 | ||||
| 11. Round | 20/04/2022 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 | ||||
| 12. Round | 24/04/2022 | San Lorenzo II | - | Patronato de Paraná II | 3:0 | |
Argentina