| 2. Round | 25/08/2021 | TJ Kovo Beluša | - | Spartak Trnava | 0:3 | ||||
| 3. Round | 14/09/2021 | FC Pata | - | Spartak Trnava | 0:4 | ||||
| 4. Round | 26/10/2021 | FK Železiarne Podbrezová | - | Spartak Trnava | 6:7 pso | ||||
| Semi-finals | 06/04/2022 | Spartak Trnava | - | FK Senica | 3:0 | ||||
| Semi-finals | 20/04/2022 | FK Senica | - | Spartak Trnava | 0:4 |  |
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| Final | 08/05/2022 | Slovan Bratislava | - | Spartak Trnava | 1:2 aet |
Slovakia