| 5. Round | 03/10/2021 | CD Toledo | - | CD Marchamalo | 3:2 | ||||
| 8. Round | 24/10/2021 | Mar Menor CF | - | CD Toledo | 2:0 |  |
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| 10. Round | 07/11/2021 | UD Socuéllamos | - | CD Toledo | 1:1 | ||||
| 12. Round | 21/11/2021 | Levante UD B | - | CD Toledo | 0:2 | |
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| 17. Round | 09/01/2022 | CD Toledo | - | Real Murcia | 0:3 | ||||
| 29. Round | 10/04/2022 | CD Toledo | - | Levante UD B | 2:2 | ||||
| 30. Round | 17/04/2022 | CD El Ejido 2012 | - | CD Toledo | 1:2 | ||||
| 32. Round | 01/05/2022 | CD Eldense | - | CD Toledo | 3:1 | ||||
| 34. Round | 15/05/2022 | Real Murcia | - | CD Toledo | 2:0 |
Spain