| 1. Round | 05/09/1980 | Sporting Gijón | - | Real Betis | 2:0 | ||||
| 5. Round | 05/10/1980 | Real Sociedad | - | Real Betis | 2:2 | ||||
| 8. Round | 26/10/1980 | FC Barcelona | - | Real Betis | 1:3 | ||||
| 14. Round | 06/12/1980 | Athletic Club | - | Real Betis | 2:0 | ||||
| 20. Round | 17/01/1981 | Real Betis | - | CA Osasuna | 1:1 |  |
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| 21. Round | 23/01/1981 | UD Las Palmas | - | Real Betis | 2:4 | ||||
| 22. Round | 31/01/1981 | Real Betis | - | Real Sociedad | 1:0 | ||||
| 23. Round | 07/02/1981 | Atlético Madrid | - | Real Betis | 0:4 | ||||
| 24. Round | 14/02/1981 | Hércules CF | - | Real Betis | 0:1 | ||||
| 25. Round | 21/02/1981 | Real Betis | - | FC Barcelona | 1:1 | ||||
| 27. Round | 07/03/1981 | Real Betis | - | Real Zaragoza | 2:0 | ||||
| 28. Round | 14/03/1981 | Real Madrid | - | Real Betis | 4:2 | ||||
| 29. Round | 21/03/1981 | Real Betis | - | Real Valladolid | 2:2 | ||||
| 30. Round | 28/03/1981 | AD Almería | - | Real Betis | 0:2 | ||||
| 31. Round | 04/04/1981 | Real Betis | - | Athletic Club | 2:0 | ||||
| 32. Round | 11/04/1981 | Sevilla FC | - | Real Betis | 2:1 | ||||
| 33. Round | 18/04/1981 | Real Betis | - | Real Murcia | 1:0 | ||||
| 34. Round | 25/04/1981 | Espanyol Barcelona | - | Real Betis | 1:2 |
Spain