| 1. Round | 19/09/1981 | Racing Santander | - | Real Betis | 2:1 | ||||
| 2. Round | 26/09/1981 | Real Betis | - | Real Sociedad | 0:1 | ||||
| 3. Round | 04/10/1981 | Atlético Madrid | - | Real Betis | 1:0 | ||||
| 4. Round | 07/10/1981 | Real Betis | - | Sevilla FC | 2:0 | ||||
| 9. Round | 07/11/1981 | CA Osasuna | - | Real Betis | 0:1 | ||||
| 10. Round | 10/11/1981 | Real Betis | - | Athletic Club | 2:1 |  |
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| 11. Round | 14/11/1981 | Real Madrid | - | Real Betis | 4:1 | ||||
| 15. Round | 12/12/1981 | Real Betis | - | Sporting Gijón | 2:0 | ||||
| 19. Round | 09/01/1982 | Real Sociedad | - | Real Betis | 1:0 | ||||
| 20. Round | 16/01/1982 | Real Betis | - | Atlético Madrid | 3:1 | ||||
| 21. Round | 23/01/1982 | Sevilla FC | - | Real Betis | 1:1 | |
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| 23. Round | 06/02/1982 | Real Zaragoza | - | Real Betis | 3:3 | ||||
| 24. Round | 12/02/1982 | Real Betis | - | Valencia CF | 2:3 | ||||
| 25. Round | 20/02/1982 | Espanyol Barcelona | - | Real Betis | 2:4 | ||||
| 26. Round | 27/02/1982 | Real Betis | - | CA Osasuna | 2:0 | ||||
| 27. Round | 06/03/1982 | Athletic Club | - | Real Betis | 5:1 | ||||
| 30. Round | 27/03/1982 | Cádiz CF | - | Real Betis | 0:2 |
Spain