| 20. Round | 09/01/2016 | Angers SCO | - | SM Caen | 2:0 | ||||
| 21. Round | 15/01/2016 | OGC Nice | - | Angers SCO | 2:1 | ||||
| 22. Round | 23/01/2016 | Paris Saint-Germain | - | Angers SCO | 5:1 | ||||
| 23. Round | 30/01/2016 | Angers SCO | - | AS Monaco | 3:0 | ||||
| 24. Round | 03/02/2016 | Stade de Reims | - | Angers SCO | 2:1 | ||||
| 25. Round | 06/02/2016 | Angers SCO | - | Olympique Lyonnais | 0:3 | ||||
| 28. Round | 27/02/2016 | EA Guingamp | - | Angers SCO | 2:2 | ||||
| 29. Round | 05/03/2016 | Angers SCO | - | AS Saint-Étienne | 0:0 | ||||
| 30. Round | 13/03/2016 | FC Nantes | - | Angers SCO | 2:0 | ||||
| 31. Round | 19/03/2016 | Angers SCO | - | FC Lorient | 5:1 | ||||
| 32. Round | 02/04/2016 | ESTAC Troyes | - | Angers SCO | 0:1 | ||||
| 33. Round | 09/04/2016 | Angers SCO | - | Gazélec FC Ajaccio | 0:0 | ||||
| 34. Round | 16/04/2016 | Girondins Bordeaux | - | Angers SCO | 1:3 | ||||
| 35. Round | 27/04/2016 | Lille OSC | - | Angers SCO | 0:0 |  |
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| 36. Round | 01/05/2016 | Angers SCO | - | Olympique Marseille | 0:1 | ||||
| 37. Round | 07/05/2016 | SC Bastia | - | Angers SCO | 1:0 | ||||
| 38. Round | 14/05/2016 | Angers SCO | - | Toulouse FC | 2:3 |
France