| 1. Round | 30/07/1999 | RC Strasbourg | - | RC Lens | 1:0 | ||||
| 2. Round | 05/08/1999 | SC Bastia | - | RC Strasbourg | 3:0 | ||||
| 3. Round | 13/08/1999 | RC Strasbourg | - | Montpellier HSC | 2:0 | ||||
| 4. Round | 19/08/1999 | ATAC Troyes | - | RC Strasbourg | 2:1 | ||||
| 5. Round | 27/08/1999 | RC Strasbourg | - | Stade Rennais | 2:1 | ||||
| 6. Round | 10/09/1999 | FC Metz | - | RC Strasbourg | 0:0 | ||||
| 7. Round | 18/09/1999 | RC Strasbourg | - | Paris Saint-Germain | 1:1 | ||||
| 8. Round | 24/09/1999 | Olympique Lyonnais | - | RC Strasbourg | 0:0 | ||||
| 9. Round | 01/10/1999 | RC Strasbourg | - | Girondins Bordeaux | 2:2 | ||||
| 10. Round | 12/10/1999 | RC Strasbourg | - | AJ Auxerre | 1:3 | ||||
| 11. Round | 15/10/1999 | AS Monaco | - | RC Strasbourg | 3:0 | ||||
| 12. Round | 23/10/1999 | RC Strasbourg | - | FC Nantes | 3:2 | ||||
| 13. Round | 29/10/1999 | Olympique Marseille | - | RC Strasbourg | 4:1 | ||||
| 16. Round | 18/11/1999 | RC Strasbourg | - | Havre AC | 0:1 | ||||
| 17. Round | 26/11/1999 | AS Saint-Étienne | - | RC Strasbourg | 0:1 | ||||
| 18. Round | 02/12/1999 | RC Strasbourg | - | SC Bastia | 2:0 | ||||
| 19. Round | 10/12/1999 | Montpellier HSC | - | RC Strasbourg | 1:1 |
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