| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | ||||
| 17. Round | 05/02/2022 | Angers SCO B | - | FC Nantes B | 1:0 |  |
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| 18. Round | 12/02/2022 | Canet Roussillon | - | Angers SCO B | 2:0 | ||||
| 19. Round | 19/02/2022 | Angers SCO B | - | Angoulême CFC | 0:0 | ||||
| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO B | 1:1 | ||||
| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | |
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| 23. Round | 26/03/2022 | Angers SCO B | - | Stade Montois | 0:0 | ||||
| 24. Round | 09/04/2022 | Bourges Foot 18 | - | Angers SCO B | 0:1 | ||||
| 28. Round | 14/05/2022 | Angers SCO B | - | Montpellier HSC B | 1:0 | |
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| 29. Round | 21/05/2022 | FC Chamalières | - | Angers SCO B | 1:0 |
France
Cameroon