| 1. Round | 08/09/2000 | Deportivo La Coruña | - | Athletic Club | 2:0 |  |
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| 2. Round | 15/09/2000 | Athletic Club | - | FC Barcelona | 3:1 | |
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| 3. Round | 22/09/2000 | Real Madrid | - | Athletic Club | 4:1 | ||||
| 5. Round | 14/10/2000 | CD Numancia | - | Athletic Club | 0:0 | |
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| 6. Round | 21/10/2000 | Athletic Club | - | UD Las Palmas | 0:3 | ||||
| 7. Round | 27/10/2000 | Villarreal CF | - | Athletic Club | 0:0 | ||||
| 8. Round | 31/10/2000 | Athletic Club | - | Real Zaragoza | 1:2 | |
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| 9. Round | 04/11/2000 | CA Osasuna | - | Athletic Club | 1:1 | ||||
| 10. Round | 11/11/2000 | Athletic Club | - | RC Celta | 2:1 | ||||
| 11. Round | 18/11/2000 | Espanyol Barcelona | - | Athletic Club | 2:1 | ||||
| 12. Round | 25/11/2000 | Athletic Club | - | Rayo Vallecano | 4:2 | ||||
| 13. Round | 02/12/2000 | CD Alavés | - | Athletic Club | 2:1 | ||||
| 14. Round | 09/12/2000 | Athletic Club | - | Real Oviedo | 4:0 | ||||
| 15. Round | 16/12/2000 | Real Valladolid | - | Athletic Club | 0:0 | ||||
| 35. Round | 17/05/2001 | Valencia CF | - | Athletic Club | 1:0 | ||||
| 36. Round | 26/05/2001 | Athletic Club | - | Málaga CF | 1:3 | ||||
| 37. Round | 09/06/2001 | Athletic Club | - | Real Sociedad | 1:3 | |
Spain