| 1. Round | 16/08/2024 | Jura Sud | - | FC Istres | 2:0 | ||||
| 2. Round | 24/08/2024 | FC Istres | - | Marignane Gignac | 2:1 |  |
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| 3. Round | 30/08/2024 | AS Saint-Priest | - | FC Istres | 1:0 | ||||
| 4. Round | 07/09/2024 | FC Istres | - | Les Genêts d'Anglet | 2:0 | |
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| 5. Round | 14/09/2024 | Hyères FC | - | FC Istres | 0:0 | ||||
| 6. Round | 20/09/2024 | FC Istres | - | Angoulême CFC | 0:0 | ||||
| 7. Round | 05/10/2024 | Étoile FC | - | FC Istres | 3:1 | ||||
| 8. Round | 18/10/2024 | FC Istres | - | GOAL FC | 3:2 | |
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| 9. Round | 02/11/2024 | RC Grasse | - | FC Istres | 2:0 | ||||
| 10. Round | 09/11/2024 | Bergerac Périgord FC | - | FC Istres | 3:0 | ||||
| 12. Round | 07/12/2024 | AS Cannes | - | FC Istres | 4:1 | |
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| 13. Round | 13/12/2024 | FC Istres | - | Andrézieux-Bouthéon FC | 0:0 | ||||
| 14. Round | 21/12/2024 | GFA Rumilly Vallières | - | FC Istres | 1:2 | |
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| 15. Round | 10/01/2025 | FC Istres | - | Le Puy Foot 43 | 1:4 | ||||
| 16. Round | 18/01/2025 | Marignane Gignac | - | FC Istres | 2:7 | |
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| 17. Round | 24/01/2025 | FC Istres | - | AS Saint-Priest | 0:2 | ||||
| 20. Round | 21/02/2025 | Angoulême CFC | - | FC Istres | 1:0 | ||||
| 23. Round | 22/03/2025 | FC Istres | - | RC Grasse | 4:2 | ||||
| 24. Round | 04/04/2025 | FC Istres | - | Bergerac Périgord FC | 0:2 |
France